The Directorate of Enforcement, with its Headquarters at New Delhi is headed the Director of Enforcement. There are two Special Directors, one Additional Director and two Deputy Directors at Head Office. There is a Legal Wing at Headquarters Office headed by the Additional Director (Prosecution). In addition, there is one Special Director posted at Mumbai.

There are ten Zonal Offices of the Directorate at Ahmedabad, Bangalore, Chandigarh, Chennai, Cochin, Delhi, Hyderabad, Kolkata, Lucknow and Mumbai. The Zonal Offices are headed by the Deputy Directors.

The Directorate has eleven Sub Zonal Offices at Bhubaneswar, Calicut, Guwahati, Indore, Jaipur, Jalandhar, Madurai, Nagpur, Patna, Srinagar and Varanasi, which are headed by the Assistant Directors.